Disulfiram
 
Disulfiram, also known as Antabuse, blocks the normal metabolism of alcohol so that when someone drinks while taking this medication, they experience a very unpleasant reaction that can include flushing, nausea, vomiting, headaches, chest pain, blurred vision, confusion, respiratory difficulty, and palpitations. This reaction can last for 12 hours and persist as long as 14 days after the last dose of disulfiram. There is a risk of liver damage with disulfiram, so patients taking this drug must have regular blood tests. Although disulfiram has been used for helping alcoholics stay sober for more than 30 years, the severity of this reaction has limited its widespread use.  It is sometimes useful in selected high-risk situations to prevent a relapse.
​