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Prazosin

Prazosin, is an older medication used for hypertension and for men with urine flow issues associated with the prostate gland.  Prazosin is also used “off label” in post traumatic stress disorder and to reduce the impact of the terrifying dreams that accompany this disorder.  In one research study, when patients were given it for this purpose, they noticed they lost their desire to drink.  This led to other studies suggesting that prazosin may help alcoholics maintain sobriety.  Prazosin is a difficult medicine to take, however, because it must be taken three times a day, and the dose must be increased slowly over several weeks.  As a blood pressure medicine, it can cause excessively low blood pressure, and the most common side effect of prazosin is fainting.  Fainting may occur when standing suddenly.  

 

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©2025 by John Umhau MD MPH

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